NF AI

Adverse-event extraction from neurofibromatosis clinical-trial literature, harmonized to CTCAE v6 and queryable across studies.

Project overview

What this is

NF AI automates the slowest step of clinical-evidence review for neurofibromatosis trials — pulling adverse-event tables out of published papers, mapping the free-text terms to a controlled vocabulary, and stacking the result so different drugs and dose regimens can be compared on the same axes.

Today the corpus covers selumetinib, mirdametinib, trametinib, brigatinib, axitinib, and bevacizumab arms across NF1 and NF2. New PubMed candidates land daily through a deterministic poller; eligible papers are extracted, harmonized, and surfaced for human review before joining the database.

Four stages

How the data flows

Stage 1
Discovery

A deterministic PubMed poller fires every 4 hours. Each tick widens its recency window if recent ticks were dry, and PMIDs are deduplicated at three layers (in-memory set, file-glob, partial-unique DB index).

Stage 2
Relevance gate

A keyword-first scorer ranks each candidate; the uncertain band (score 2–3) gets a Claude adjudication hop. Score ≥ 4 with AE data auto-approves; everything else queues for human review.

Stage 3
Extraction & harmonization

Approved candidates pass through Claude vision/text extraction. Free-text AE terms are mapped to CTCAE v6 by sentence-transformer embedding similarity, with an LLM fallback for low-confidence rows.

Stage 4
Cross-study comparison

Harmonized rows feed Compare's per-grade severity bars, MedDRA SOC heatmap, and risk-ratio forest plots. Wilson 95 % CI on every reporting rate; Katz log-transform CIs on every RR.

By role

What you can do here

Reader

Browse Database, Compare, Literature.

Leave comments inline; drop by the design-system page to see the kit.

No signup needed for read; sign in to comment.

Reviewer

Sign in. Once an admin grants the relevant permission you can run extraction, save studies to the database, or approve candidates from the queue.

Default for new accounts is view + comment only — operators grant capabilities per-user from the admin Users panel.

Operator

Superuser only.

Admin → Users & permissions to grant per-user capabilities; Monitor for live pipeline state; Settings + Agents for runtime knobs.

External

References

  • Children's Tumor Foundation— workshop sponsor — CTF AI Workshop, June 27–28 2026.
  • NCI CTCAE v6.0— Common Terminology Criteria for Adverse Events; the AE-grade scale this site harmonizes to.
  • MedDRA— System Organ Class hierarchy used for grouping AE terms in Compare’s SOC heatmap.
  • Anthropic API— Claude vision + text used by the extraction stage; per-candidate cost recorded in the cost_events table.